Serial changes of NS5A P32deletion mutant in HCV genotype 1b patients after Daclatasvir/Asunaprevir failure
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چکیده
منابع مشابه
Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay
Daclatasvir and asunaprevir dual oral therapy is expected to achieve high sustained virological response (SVR) rates in patients with HCV genotype 1b infection. However, presence of the NS5A-Y93H substitution at baseline has been shown to be an independent predictor of treatment failure for this regimen. By using the Invader assay, we developed a system to rapidly and accurately detect the pres...
متن کاملSequencing of E2 and NS5A regions of HCV genotype 3a in Brazilian patients with chronic hepatitis.
Hepatitis C virus (HCV) is a major cause of liver disease throughout the world. The NS5A and E2 proteins of HCV genotype 1 were reported to inhibit the double-stranded (ds) RNA-dependent protein kinase (PKR), which is involved in the cellular antiviral response induced by interferon (IFN). The response to IFN therapy is quite different between genotypes, with response rates among patients infec...
متن کاملAmino Acid Polymorphisms Within the Entire HCV NS5A Region in Estonian Chronic HCV 1b Patients With Different Treatment Response
BACKGROUND A substantial proportion of hepatitis C virus (HCV)-1b infected patients do not response to pegylated interferon-α plus ribavirin (PegIFNα/RBV) combination therapy that was partially associated with mutations in the non-structural 5A (NS5A) protein. OBJECTIVES Analysis of NS5A polymorphisms in HCV genotype 1b pre-treatment serum samples from Estonian patients and their effect on th...
متن کاملHCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b
BACKGROUND The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated interferon (PEG-IFN) plus ribavirin...
متن کاملamino acid polymorphisms within the entire hcv ns5a region in estonian chronic hcv 1b patients with different treatment response
objectives analysis of ns5a polymorphisms in hcv genotype 1b pre-treatment serum samples from estonian patients and their effect on the treatment response. patients and methods twenty-nine complete ns5a sequences obtained from patients with chronic hcv-1b infection who had received combined therapy with pegifnα-2a/rbv were analyzed and compared with the prototype strain hcv-j. twelve patients a...
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ژورنال
عنوان ژورنال: Kanzo
سال: 2018
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.59.230